입수한 문건의 말을 인용하면, 우울감 부작용 보고는 적은 숫자가 아니었다. 2002년부터 MSD는 프로페시아를 복용하는 여성들에게서 자살 충동을 함유한 900개 이상의 우울증 보고를 취득했다. 그러나 MSD는 위험한 우울감과 자살 행동에 대한 보고가 너무 적으며, 안전성에 대한 모니터링 이상을 요구할만큼 구체적인 사례가 없다는 이유로 후속조치를 하지 않았다.
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